Fluid Resuscitation in Paediatric Sepsis

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Thanks to Elliot Long from the Children's Hospital here in Melbourne for talking to us about fluid therapy in paediatric sepsis. 

Full talk below, (mentioned studies linked below).



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Further Reading / Viewing

This is a film about the FEAST Clinical Trial, a groundbreaking clinical trial funded by the Medical Research Council, London, and published in the New England Journal of Medicine.

Long E, Duke T. Fluid resuscitation therapy for paediatric sepsis. J Paediatr Child Health. 2016 Feb;52(2):141-6. doi: 10.1111/jpc.13085.

Maitland K, et al and the FEAST Trial Group. Mortality after Fluid Bolus in African Children with Severe Infection. N Engl J Med. 2011 May 26. [Epub ahead of print]

Maitland K, et al; FEAST trial group. Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med. 2013 Mar 14;11:68. doi: 10.1186/1741-7015-11-68. 

Myburgh J, Finfer S. Causes of death after fluid bolus resuscitation: new insights from FEAST. BMC Med. 2013 Mar 14;11:67. doi: 10.1186/1741-7015-11-67. 

Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R; SPLIT Investigators; ANZICS CTG. Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial.. JAMA. 2015 Oct 27;314(16):1701-10. doi: 10.1001/jama.2015.12334.

Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010 Feb 24;303(8):739-46. doi: 10.1001/jama.2010.158.

ARISE Investigators; ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1.