Fluid Resuscitation in Paediatric Sepsis

Image Source Link

Image Source Link

Thanks to Elliot Long from the Children's Hospital here in Melbourne for talking to us about fluid therapy in paediatric sepsis. 

Full talk below, (mentioned studies linked below).

 

Podcast:

Subscribe: iTunes | Android | RSS  

 

Further Reading / Viewing

This is a film about the FEAST Clinical Trial, a groundbreaking clinical trial funded by the Medical Research Council, London, and published in the New England Journal of Medicine.

Long E, Duke T. Fluid resuscitation therapy for paediatric sepsis. J Paediatr Child Health. 2016 Feb;52(2):141-6. doi: 10.1111/jpc.13085.

Maitland K, et al and the FEAST Trial Group. Mortality after Fluid Bolus in African Children with Severe Infection. N Engl J Med. 2011 May 26. [Epub ahead of print]

Maitland K, et al; FEAST trial group. Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med. 2013 Mar 14;11:68. doi: 10.1186/1741-7015-11-68. 

Myburgh J, Finfer S. Causes of death after fluid bolus resuscitation: new insights from FEAST. BMC Med. 2013 Mar 14;11:67. doi: 10.1186/1741-7015-11-67. 

Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, McGuinness S, Mehrtens J, Myburgh J, Psirides A, Reddy S, Bellomo R; SPLIT Investigators; ANZICS CTG. Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial.. JAMA. 2015 Oct 27;314(16):1701-10. doi: 10.1001/jama.2015.12334.

Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010 Feb 24;303(8):739-46. doi: 10.1001/jama.2010.158.

ARISE Investigators; ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1.